Identification of CXCL12 as a key gene of trophoblast and endometrial stromal cell decidualization in pregnancy via scRNA-seq and experimental validation

CXCL12 promotes the proliferation, migration, and invasion ability of trophoblast cells <i>in vitro</i> and promotes the decidualization of endometrial stromal cells. The downregulation of the CXCL12/CXCR4 axis may be involved in the occurrence and development of RM. Thus, this study provides experimental clues for exploring potential therapeutic approaches related to CXCL12.

Authors

Institutions

Publication Details

Journal
Frontiers in Molecular Biosciences
Published
2026-01-30
DOI
https://doi.org/10.3389/fmolb.2026.1768015
Primary Topic
Reproductive System and Pregnancy
Type
article
Field-Weighted Citation Impact
0.00

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Identification of CXCL12 as a key gene of trophoblast and endometrial stromal cell decidualization in pregnancy via scRNA-seq and experimental validation

Haimei Yang, Zhe Leng, H. Eugene Liu, Zhou Jiang et al.
Frontiers in Molecular Biosciences
Reproductive System and Pregnancy
article

Identification of CXCL12 as a key gene of trophoblast and endometrial stromal cell decidualization in pregnancy via scRNA-seq and experimental validation

Haimei Yang, Zhe Leng, H. Eugene Liu, Zhou Jiang, Xianli Sun, Wei Zhang
article en

Abstract

CXCL12 promotes the proliferation, migration, and invasion ability of trophoblast cells <i>in vitro</i> and promotes the decidualization of endometrial stromal cells. The downregulation of the CXCL12/CXCR4 axis may be involved in the occurrence and development of RM. Thus, this study provides experimental clues for exploring potential therapeutic approaches related to CXCL12.

Frontiers in Molecular BiosciencesVol. 13
Qingdao University (CN), Binzhou Medical University (CN), Shandong University of Aeronautics (CN), Maternal Child and Family Health (US), First People's Hospital of Chongqing (CN), Shandong First Medical University (CN), Qingdao Women and Children's Hospital (CN)
Centre Scientifique et Technique du Bâtiment
Good health and well-being
Openalex Percentile: Top 73%
Reproductive System and Pregnancy
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

Identification of CXCL12 as a key gene of trophoblast and endometrial stromal cell decidualization in pregnancy via scRNA-seq and experimental validation — Haimei Yang, Zhe Leng, et al. · Frontiers in Molecular Biosciences (2026) | TGRS Research Map | TGRS