Diagnostic assessment of Hirschsprung disease using fluorescence confocal microscopy: A feasibility study
FCM is an easy-to-implement method for identifying normal and affected bowel in HD. It is used on unfixed specimens, preserving the tissue quality. Its diagnostic accuracy is comparable to that of frozen sections in assessable samples, and it is advantageous in cases where local access to expert pathologists is limited.
Authors
- Florian Friedmacher (ORCID: https://orcid.org/0000-0002-7900-6004)
- Till‐Martin Theilen
- Yannick Braun (ORCID: https://orcid.org/0000-0002-2939-4512)
- Elise Gradhand (ORCID: https://orcid.org/0000-0003-3143-0487)
- U Rolle
- Steffen Gretser (ORCID: https://orcid.org/0000-0002-4875-3808)
- Henning C. Fiegel
- Barbara Walczak
- Peter Wild
Institutions
- Goethe University Frankfurt (DE)
- Christian-Albrechts-Universität zu Kiel (DE)
- University Hospital Schleswig-Holstein (DE)
- University Hospital Frankfurt (DE)
- University of Lübeck (DE)
Publication Details
- Journal
- Journal of Pediatric Surgery
- Published
- 2026-01-30
- DOI
- https://doi.org/10.1016/j.jpedsurg.2026.162973
- Primary Topic
- Congenital gastrointestinal and neural anomalies
- Type
- article
- Field-Weighted Citation Impact
- 0.00