Ferulic acid activates Nrf2/HO-1 signaling axis to ameliorate neuronal Golgi stress by SKP2
FA reduced neuronal Golgi stress in H<sub>2</sub>O<sub>2</sub>-treated neuronal cells by restoring the Nrf2/HO-1 signaling through inhibiting Src-mediated SKP2 phosphorylation. These findings indicate that FA is a potential neuroprotective agent.
Authors
- Xiaohui Qin
- Gangjian Tang
- Qinghua Dong (ORCID: https://orcid.org/0000-0001-9242-6655)
- Aiguo Li (ORCID: https://orcid.org/0000-0003-0039-3695)
- Wencong Xu
- Xinwei Zhao
- Chao Liu
Institutions
- Macau University of Science and Technology (MO)
- Guilin Medical University (CN)
- 181st Hospital of Chinese People's Liberation Army (CN)
- Affiliated Hospital of Guilin Medical College (CN)
Publication Details
- Journal
- Journal of Pharmacological Sciences
- Published
- 2026-01-29
- DOI
- https://doi.org/10.1016/j.jphs.2026.01.006
- Primary Topic
- Genomics, phytochemicals, and oxidative stress
- Type
- article
- Field-Weighted Citation Impact
- 0.00