Improvement in anemia and symptoms after switching from crovalimab to iptacopan in paroxysmal nocturnal hemoglobinuria

Switching to iptacopan led to rapid and durable improvement in anemia and symptoms, supporting proximal complement inhibition as a valuable option for PNH patients inadequately controlled with C5 inhibitors.

Authors

Institutions

Publication Details

Journal
Hematology
Published
2026-01-29
DOI
https://doi.org/10.1080/16078454.2026.2620152
Primary Topic
Complement system in diseases
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Improvement in anemia and symptoms after switching from crovalimab to iptacopan in paroxysmal nocturnal hemoglobinuria

Masako Toyosaki, Sawako Shiraiwa, Shunsuke Tomita, M. Endo et al.
Hematology
Complement system in diseases
article

Improvement in anemia and symptoms after switching from crovalimab to iptacopan in paroxysmal nocturnal hemoglobinuria

Masako Toyosaki, Sawako Shiraiwa, Shunsuke Tomita, M. Endo, Daisuke Ogiya, Yoshiaki Ogawa, Makoto Onizuka, Miina Nasukawa, Hiroshi Kawada, Shinichiro Machida, Seina Koyama
article en

Abstract

Switching to iptacopan led to rapid and durable improvement in anemia and symptoms, supporting proximal complement inhibition as a valuable option for PNH patients inadequately controlled with C5 inhibitors.

HematologyVol. 31(1)
Tokai University (JP)
Zero hunger
Openalex Percentile: Top 73%
Complement system in diseases
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.