The multifaceted behavior of electron attachment in 8-bromo-purine derivatives and the connection with DNA damage <sup>†</sup>
Based on radiation chemistry, our understanding of the one-electron reduction of 8-Br-dA and 8-Br-dG has been enhanced substantially. This mechanistic background is crucial for a better understanding of and addressing their significant roles in the biological environment, such as DNA radiosensitizers for cancer radiation therapy or as biomarkers for early inflammation.
Authors
- Chryssostomos Chatgilialoglu (ORCID: https://orcid.org/0000-0003-2626-2925)
Institutions
- Institute of Organic Synthesis and Photoreactivity (IT)
- Adam Mickiewicz University in Poznań (PL)
Publication Details
- Journal
- International Journal of Radiation Biology
- Published
- 2026-01-29
- DOI
- https://doi.org/10.1080/09553002.2026.2617595
- Primary Topic
- DNA Repair Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00