Enhanced CHI3L1 promotes macrophage activation in persistent inflammatory events of ulcerative interstitial cystitis

CHI3L1 exacerbates PIEs in HIC by reprogramming macrophage metabolism toward glycolysis and sustaining inflammation via MYC signaling. These findings establish CHI3L1 as a central regulator of chronic inflammation in HIC and highlight its potential as a therapeutic target for disrupting pathological immune-metabolic cycles.

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Publication Details

Journal
Frontiers in Immunology
Published
2026-01-29
DOI
https://doi.org/10.3389/fimmu.2026.1716297
Primary Topic
Urinary Bladder and Prostate Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Enhanced CHI3L1 promotes macrophage activation in persistent inflammatory events of ulcerative interstitial cystitis

Yize Guo, Jiawen Wang, Ting Xie, Yao Li et al.
Frontiers in Immunology
Urinary Bladder and Prostate Research
article

Enhanced CHI3L1 promotes macrophage activation in persistent inflammatory events of ulcerative interstitial cystitis

Yize Guo, Jiawen Wang, Ting Xie, Yao Li, Wei Zhang, Xiaodong Liu
article en

Abstract

CHI3L1 exacerbates PIEs in HIC by reprogramming macrophage metabolism toward glycolysis and sustaining inflammation via MYC signaling. These findings establish CHI3L1 as a central regulator of chronic inflammation in HIC and highlight its potential as a therapeutic target for disrupting pathological immune-metabolic cycles.

Frontiers in ImmunologyVol. 17
Qingdao University (CN), Army Medical University (CN), First Affiliated Hospital of Guangzhou Medical University (CN), Affiliated Hospital of Qingdao University (CN), Xinqiao Hospital (CN), Fujian Provincial Hospital (CN), Guangzhou Medical University (CN)
Good health and well-being
Openalex Percentile: Top 74%
Urinary Bladder and Prostate Research
DOIOpen Access PDFOpenAlex
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Enhanced CHI3L1 promotes macrophage activation in persistent inflammatory events of ulcerative interstitial cystitis — Yize Guo, Jiawen Wang, et al. · Frontiers in Immunology (2026) | TGRS Research Map | TGRS