Araliadiol Protects Human Keratinocytes From Oxidative Stress, DNA Damage, and Apoptosis via Activation of Antioxidant Signaling

Our findings suggest that UPM exposure alone elicited limited stress-adaptive antioxidant responses without effective cytoprotection. In contrast, araliadiol treatment independently activated robust antioxidant and cytoprotective signaling. Moreover, under UPM exposure, araliadiol further enhanced cellular defense through the activation of the Nrf2 and JNK-AP-1 signaling pathways. These results highlight the therapeutic potential of araliadiol as a dermoprotective agent derived from <i>Centella asiatica</i>, particularly in mitigating pollutant-induced skin damage.