Neuroprotective Effects of the SIRT3/AMPK Axis in Experimental Glaucoma
This study provides the first comprehensive <i>in vivo</i> and <i>in vitro</i> evidence in glaucoma models that SIRT3 confers neuroprotection in experimental glaucoma, primarily through activation of the AMPK signaling pathway. These findings identify the SIRT3/AMPK axis as a novel mechanistic target and suggest a promising therapeutic strategy for IOP-independent neuroprotection in glaucoma.
Authors
- Ying Yu
- Feng Chen (ORCID: https://orcid.org/0000-0002-0362-7242)
- Xiaoxiao Cai
- Xiaohe Lu
Institutions
- Guangzhou Women and Children Medical Center (CN)
- Zhujiang Hospital (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2026-01-14
- DOI
- https://doi.org/10.31083/fbl46525
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 0.00