Mechanisms of Bellidifolin in Treating Doxorubicin-Induced Cardiotoxicity: Network Pharmacology, Molecular Docking, and Experimental Verification
BEL presents as a promising therapeutic candidate for cardiotoxicity, likely through its anti-fibrotic effects via the reduction of TGF-β1, α-SMA, Col I, and Col III expression, alongside regulation in the PI3K-AKT signaling pathway.
Authors
- Aiying Li (ORCID: https://orcid.org/0000-0001-7779-1814)
- Fan Gao (ORCID: https://orcid.org/0000-0002-8707-0436)
- Jiangli Wu (ORCID: https://orcid.org/0000-0002-8330-3677)
- Yu Liu
- Zhenyang Zhong
- Yalei Liu
- Cheng Dai
- Xinmeng Zhao
Institutions
- Hebei University of Chinese Medicine (CN)
- Hebei Science and Technology Department (CN)
- Hebei Institute of Physical Education (CN)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2026-01-21
- DOI
- https://doi.org/10.31083/fbl47028
- Primary Topic
- Chemotherapy-induced cardiotoxicity and mitigation
- Type
- article
- Field-Weighted Citation Impact
- 0.00