CD4+ T cell dysregulation in major depressive disorder is associated with sleep disturbance
Our findings demonstrate that patients with MDD comorbid with sleep disturbances exhibit elevated proportions of CD4<sup>+</sup> T cells compared to those without such disturbance. These results suggest that targeted interventions addressing sleep disruption may contribute to restoring CD4<sup>+</sup> T cell homeostasis, potentially offering a novel therapeutic strategy for MDD management.
Authors
- Xianyan Zhan
- Yao Gao (ORCID: https://orcid.org/0000-0003-1957-7232)
- Ziyang Zhou (ORCID: https://orcid.org/0000-0003-3730-0157)
- Xiancang Ma
- Zihan Lei
- Zirong Chen
- Yifan Ren
- Pan Li
- Zuer Guo
Institutions
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Frontiers in Psychiatry
- Published
- 2026-01-29
- DOI
- https://doi.org/10.3389/fpsyt.2026.1763750
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China