Dendrobine attenuates postoperative cognitive dysfunction by inhibiting Runx1-mediated NF-κB signaling pathway
Dendrobine ameliorates POCD by inhibiting the Runx1/NF-κB signaling pathway, suppressing neuroinflammation, promoting synaptic resilience, and preventing neuronal apoptosis. Runx1 appears to act as a key upstream mediator of NF-κB signaling in POCD. Targeting the Runx1/NF-κB axis represents a promising strategy for perioperative neuroprotection.
Authors
- Chengcheng Zhang (ORCID: https://orcid.org/0000-0001-5786-4748)
- Hongbing Wang (ORCID: https://orcid.org/0000-0003-4811-8617)
- X. Yan Fan
- Mingyi Zang
- Jie Liu
- Qingyu Sun
- Wei Xiao
- Dong Ji
Institutions
- Tongji University (CN)
- Second Military Medical University (CN)
- Changhai Hospital (CN)
- Shanghai East Hospital (CN)
- People's Liberation Army 411 Hospital (CN)
Publication Details
- Journal
- Brain Research Bulletin
- Published
- 2026-01-29
- DOI
- https://doi.org/10.1016/j.brainresbull.2026.111746
- Primary Topic
- Intensive Care Unit Cognitive Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00