MUC5B rs35705950 and its association with survival in Brazilian patients with idiopathic pulmonary fibrosis: A longitudinal cohort study
In this Brazilian cohort, the MUC5B promoter variant was strongly associated with susceptibility to IPF but not with independent survival differences. Functional impairment, particularly NYHA class, remained the key prognostic factor. These findings highlight the importance of integrating genetic and clinical information in diverse populations and provide novel data from an underrepresented Latin American setting.
Authors
- Elizabeth Jauhar Cardoso Bessa (ORCID: https://orcid.org/0000-0003-2390-2405)
- Lucas Resende Martinez Araujo (ORCID: https://orcid.org/0009-0003-8439-0228)
- Marcelo Marcelo Ribeiro-Alves
- B. Rangel
- Mariana Carneiro Lopes (ORCID: https://orcid.org/0000-0002-1859-8915)
- Jeane de Souza Nogueira
- Luana Faria
- Leonardo Palermo
- Cíntia Barros Santos-Rebouças
- Cláudia Henrique da Costa
- Rogerio Rufino
- Mariana Costa Rufino
- Luís Cristóvão Porto
Institutions
- Universidade do Estado do Rio de Janeiro (BR)
- D’Or Institute for Research and Education (BR)
- Fundação Oswaldo Cruz (BR)
Publication Details
- Journal
- PLoS ONE
- Published
- 2026-01-29
- DOI
- https://doi.org/10.1371/journal.pone.0341661
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro