An epidemiological study estimating the burden of cancer risk in patients with Raynaud’s phenomenon

RP was associated with an increased risk of cancer, independent of age. We also describe varying cancer-specific risks. Future research is warranted to confirm and explore these novel observations, including potentially shared pathobiological mechanisms. Key Points • RP was associated with an overall increased risk of all cancers in younger (<45years) and older (≥45 years) individuals. • There was an increased risk of certain (e.g., thorax, skin, and haematological) cancers with RP. • A reduced risk of cancer was also noted for certain cancers, especially GI-related. • Future research should confirm and explore these observations, including the pathobiology underpinning potential cancer risk in RP.

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Publication Details

Journal
Clinical Rheumatology
Published
2026-01-29
DOI
https://doi.org/10.1007/s10067-026-07961-y
Primary Topic
Systemic Sclerosis and Related Diseases
Type
article
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article

An epidemiological study estimating the burden of cancer risk in patients with Raynaud’s phenomenon

Sizheng Steven Zhao, Uazman Alam, Zsuzsanna H. McMahan, Barbara Ruaro et al.
Clinical Rheumatology
Systemic Sclerosis and Related Diseases
article

An epidemiological study estimating the burden of cancer risk in patients with Raynaud’s phenomenon

Sizheng Steven Zhao, Uazman Alam, Zsuzsanna H. McMahan, Barbara Ruaro, Michael Hughes, Edward Jude
article en

Abstract

RP was associated with an increased risk of cancer, independent of age. We also describe varying cancer-specific risks. Future research is warranted to confirm and explore these novel observations, including potentially shared pathobiological mechanisms. Key Points • RP was associated with an overall increased risk of all cancers in younger (<45years) and older (≥45 years) individuals. • There was an increased risk of certain (e.g., thorax, skin, and haematological) cancers with RP. • A reduced risk of cancer was also noted for certain cancers, especially GI-related. • Future research should confirm and explore these observations, including the pathobiology underpinning potential cancer risk in RP.

Clinical RheumatologyVol. 45(3)
Manchester Metropolitan University (GB), University of Liverpool (GB), Aintree University Hospitals NHS Foundation Trust (GB), Manchester Academic Health Science Centre (GB), Salford Royal NHS Foundation Trust (GB), University of Manchester (GB), Manchester University NHS Foundation Trust (GB), Ospedale di Cattinara (IT), Tameside and Glossop Integrated Care NHS Foundation Trust (GB), The University of Texas Health Science Center (US), NIHR Manchester Biomedical Research Centre (GB), The University of Texas Health Science Center at Houston (US)
Good health and well-being
Openalex Percentile: Top 74%
Systemic Sclerosis and Related Diseases
DOIOpen Access PDFOpenAlex
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An epidemiological study estimating the burden of cancer risk in patients with Raynaud’s phenomenon — Sizheng Steven Zhao, Uazman Alam, et al. · Clinical Rheumatology (2026) | TGRS Research Map | TGRS