Integrated single-cell and bulk RNA sequencing unravels neutrophil heterogeneity and validates SPP1 as a prognostic biomarker in cervical cancer

Our study comprehensively characterized the TME in CC through single-cell transcriptomics. Integrated analysis with bulk RNA-seq established and validated a robust prognostic signature, identifying SPP1 as a key oncogenic driver. The SPP1-centric model demonstrates significant clinical utility for risk stratification. These findings provide new insights into neutrophil heterogeneity and establish a mechanistic foundation for precision therapeutics in CC.