Advancing label-free screening technologies to enhance drug discovery efficiency

Label-free assays have rapidly advanced, offering real-time measurements, improved physiological relevance, and expanding throughput for early drug discovery. While these methods reduce artifacts and broaden target compatibility, challenges remain in validating biological relevance and managing complex kinetic data. Recent software innovations, including automated kinetic modeling and high-throughput data pipelines, are accelerating analysis and enhancing scalability.

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Publication Details

Journal
Expert Opinion on Drug Discovery
Published
2026-01-29
DOI
https://doi.org/10.1080/17460441.2026.2622372
Primary Topic
Computational Drug Discovery Methods
Type
article
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article

Advancing label-free screening technologies to enhance drug discovery efficiency

Ronghai Cheng, Chang Liu
Expert Opinion on Drug Discovery
Computational Drug Discovery Methods
article

Advancing label-free screening technologies to enhance drug discovery efficiency

Ronghai Cheng, Chang Liu
article en

Abstract

Label-free assays have rapidly advanced, offering real-time measurements, improved physiological relevance, and expanding throughput for early drug discovery. While these methods reduce artifacts and broaden target compatibility, challenges remain in validating biological relevance and managing complex kinetic data. Recent software innovations, including automated kinetic modeling and high-throughput data pipelines, are accelerating analysis and enhancing scalability.

Expert Opinion on Drug DiscoveryVol. 21(3)
Biogen (United States) (US)
Openalex Percentile: Top 71%
Computational Drug Discovery Methods
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