Immunoproteomic mediators of diabetic peripheral neuropathy: causal insights from Mendelian randomization and single-cell validation
We establish a causal neuroimmune network wherein HLA-DR<sup>+</sup> dendritic cells drive DPN through suppression of protective plasma proteins (CAPS/HLA-DRA), while MICB exerts dual protection. These findings reveal novel therapeutic targets for DPN intervention.
Authors
- Chenhao Hu (ORCID: https://orcid.org/0000-0002-0096-0488)
- S. Liu
- Shengqiao Sun
- Dezhi Li
- Chao Guo
- Lebao Yu
Institutions
- Inserm (FR)
- Capital Medical University (CN)
- Université Paris-Saclay (FR)
- Beijing Tian Tan Hospital (CN)
- Beijing Institute of Neurosurgery (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-29
- DOI
- https://doi.org/10.3389/fimmu.2026.1681223
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00