Long-term cellular and humoral responses to SARS-CoV-2 vaccinations in patients with solid malignancies undergoing chemotherapy

Despite initial impaired antibody responses to SARS-CoV-2 vaccinations, patients with solid malignancies receiving chemotherapy effectively generated long-term cellular and humoral responses by 6 and 12 months, leading to similar infection and hospitalization rates compared to healthy individuals.

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Publication Details

Journal
Frontiers in Immunology
Published
2026-01-29
DOI
https://doi.org/10.3389/fimmu.2025.1690495
Primary Topic
SARS-CoV-2 and COVID-19 Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Long-term cellular and humoral responses to SARS-CoV-2 vaccinations in patients with solid malignancies undergoing chemotherapy

Pooja Prem Advani, A E Bharucha, Gina Reynolds, Ashita Mummareddy et al.
Frontiers in Immunology
SARS-CoV-2 and COVID-19 Research
article

Long-term cellular and humoral responses to SARS-CoV-2 vaccinations in patients with solid malignancies undergoing chemotherapy

Pooja Prem Advani, A E Bharucha, Gina Reynolds, Ashita Mummareddy, Davitte Cogen, KL Knutson, Christopher P. Marquez, Melanie D. Swift, Saranya Chumsri, Mikolaj A. Wieczorek, Andrew liu, Alvaro Moreno-Aspitia, Marites Acampora, M. Necela Brian, Tushar C. Patel, Abinash Virk, Zhuo Li
article en

Abstract

Despite initial impaired antibody responses to SARS-CoV-2 vaccinations, patients with solid malignancies receiving chemotherapy effectively generated long-term cellular and humoral responses by 6 and 12 months, leading to similar infection and hospitalization rates compared to healthy individuals.

Frontiers in ImmunologyVol. 16
WinnMed (US), Cancer Clinic (US), Mayo Clinic Health System (US), Mayo Clinic in Arizona (US), Mayo Clinic in Florida (US)
Good health and well-being
Openalex Percentile: Top 71%
SARS-CoV-2 and COVID-19 Research
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Long-term cellular and humoral responses to SARS-CoV-2 vaccinations in patients with solid malignancies undergoing chemotherapy — Pooja Prem Advani, A E Bharucha, et al. · Frontiers in Immunology (2026) | TGRS Research Map | TGRS