Effect of Epigallocatechin‐3‐Gallate on Depression‐Related Cytokines in Thalassemia Patients: Molecular and Cellular Evaluation

EGCG significantly reduces the expression of depression-related inflammatory cytokines in PBMCs derived from β-thalassemia patients. These findings suggest that EGCG may have a potential modulatory role in inflammatory pathways associated with depression in thalassemia, although dose-dependent cytotoxic effects should be carefully considered.

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Publication Details

Journal
Journal of Clinical Laboratory Analysis
Published
2026-01-28
DOI
https://doi.org/10.1002/jcla.70171
Primary Topic
Tea Polyphenols and Effects
Type
article
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article

Effect of Epigallocatechin‐3‐Gallate on Depression‐Related Cytokines in Thalassemia Patients: Molecular and Cellular Evaluation

Fadhil A. Nasser, Hazim Ali Hussein, Laith A. Younus, Fouad Razzaq Al‐Burki et al.
Journal of Clinical Laboratory Analysis
Tea Polyphenols and Effects
article

Effect of Epigallocatechin‐3‐Gallate on Depression‐Related Cytokines in Thalassemia Patients: Molecular and Cellular Evaluation

Fadhil A. Nasser, Hazim Ali Hussein, Laith A. Younus, Fouad Razzaq Al‐Burki, Mohammed N. Salman, Hasanain A. A. Almohseni
article en

Abstract

EGCG significantly reduces the expression of depression-related inflammatory cytokines in PBMCs derived from β-thalassemia patients. These findings suggest that EGCG may have a potential modulatory role in inflammatory pathways associated with depression in thalassemia, although dose-dependent cytotoxic effects should be carefully considered.

Journal of Clinical Laboratory AnalysisVol. 40(4)
University of Kufa (IQ), Tohoku Medical and Pharmaceutical University (JP)
Openalex Percentile: Top 74%
Tea Polyphenols and Effects
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