Extensive Endemic Transmission of Multidrug-Resistant <i>Mycobacterium tuberculosis</i> in Bhutan: A Retrospective Genomic-Epidemiological Study
Contrary to current assumptions of repeat importations, the major burden of MDR-TB in Bhutan appears to be due to recent local transmission resulting in a large endemic cluster, advocating for targeted and enhanced contact tracing and screening for this MDR-TB clade. This study highlights the significant value of investing in TB genomics in resource-limited settings to gain actionable insights to inform policy decisions.
Authors
- Thinley Jamtsho
- Karchung Tshering (ORCID: https://orcid.org/0000-0002-3025-3784)
- Patiyan Andersson (ORCID: https://orcid.org/0000-0003-2705-1847)
- J. V. Denholm
- Pavitra Bhujel
- Wytamma Wirth (ORCID: https://orcid.org/0000-0001-7070-0078)
- Lila Adhikari (ORCID: https://orcid.org/0000-0003-3963-0336)
- Timothy P. Stinear (ORCID: https://orcid.org/0000-0003-0150-123X)
- Thinley Dorji (ORCID: https://orcid.org/0000-0003-4932-8704)
- Pema Lhaden
- Norelle L Sherry
- Benjamin P Howden
- Sonam Wangchuk
- Michelle Sait
Institutions
- The University of Melbourne (AU)
- Peter Doherty Institute (AU)
- Royal Centre for Disease Control (BT)
- Guigang City People's Hospital (CN)
- Austin Health (AU)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2025-12-26
- DOI
- https://doi.org/10.1093/ofid/ofaf802
- Citations
- 1
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.40