The Effect of Sequential Topical Application of Dermatologic Medications on Absorption: Clinical Considerations

Sequential topical application can significantly influence percutaneous absorption through barrier modification and vehicle interactions. Pharmacokinetic effects are context-dependent and cannot be inferred solely from formulation type. Mechanism-informed sequencing and judicious selection of compatible vehicles may improve predictability of topical drug delivery, highlighting the need for standardized, pharmacologically focused studies to guide application order and timing.