Unraveling the Interplay of D-2-HG in Glioblastoma Tumorigenesis via Integrated Machine Learning and Molecular Docking Analysis

Our study suggests that D-2-HG plays a significant role in the pathogenesis of GBM by modulating specific genes and signaling pathways. Utilizing machine learning techniques, we identified six essential regulatory genes, and further molecular docking simulations revealed a strong affinity of D-2-HG for these critical targets. Collectively, these results establish a substantial basis for future investigations into the mechanistic role of D-2-HG in GBM oncogenesis.