Genetic Association of Circulating Proteins and Gene Transcripts With Spontaneous Coronary Artery Dissection
Integrative analysis of proteomic, transcriptomic, and experimental data revealed 4 circulating proteins genetically associated with SCAD risk, with ECM1 emerging as a key protein with a likely causal role in SCAD pathogenesis. These findings highlight biological pathways for mechanistic studies and protein targets for potential therapeutic interventions.
Authors
- Rohin K. Reddy (ORCID: https://orcid.org/0000-0002-4726-157X)
- Brian P. Halliday (ORCID: https://orcid.org/0000-0002-5876-1748)
- Thomas R. Webb (ORCID: https://orcid.org/0000-0001-8000-0825)
- Alice Sacco (ORCID: https://orcid.org/0000-0002-8150-474X)
- J Ware (ORCID: https://orcid.org/0000-0003-1847-4952)
- Antonio de Marvao (ORCID: https://orcid.org/0000-0001-9095-5887)
- A. Schuermans
- Martina Milani (ORCID: https://orcid.org/0000-0003-4889-6988)
- Ania A. Baranowska-Clarke
- Alec Morley (ORCID: https://orcid.org/0009-0005-6021-2093)
- Paulene A. Quinn
- David Adlam
- K. H. Nicolaides
- Thong Huy Cao
- Leong L. Ng
- Buu Truong
- Adam S. Butterworth
- Michael C. Honigberg
Institutions
- Broad Institute (US)
- Harvard University (US)
- Imperial College Healthcare NHS Trust (GB)
- University of Leicester (GB)
- King's College London (GB)
- General Medical Council (GB)
- Royal Brompton & Harefield NHS Foundation Trust (GB)
- Glenfield Hospital (GB)
- University Hospitals of Leicester NHS Trust (GB)
- Harefield Hospital (GB)
- British Heart Foundation (GB)
- National Institute for Health and Care Research (GB)
- Massachusetts General Hospital (US)
- Cambridge School (PT)
- Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda (IT)
- Lung Institute (US)
- Nuffield Health (GB)
- Alessandro Manzoni Hospital (IT)
- Fetal Medicine Foundation (GB)
- Anna Needs Neuroblastoma Answers (US)
- MRC Biostatistics Unit (GB)
- Health Data Research UK (GB)
- Center for Systems Biology (US)
- Canisius College (US)
- Medical Research Council (GB)
- KU Leuven (BE)
Publication Details
- Journal
- Circulation Genomic and Precision Medicine
- Published
- 2026-01-29
- DOI
- https://doi.org/10.1161/circgen.125.005330
- Primary Topic
- Cardiovascular Issues in Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 0.00