Genetic Association of Circulating Proteins and Gene Transcripts With Spontaneous Coronary Artery Dissection

Integrative analysis of proteomic, transcriptomic, and experimental data revealed 4 circulating proteins genetically associated with SCAD risk, with ECM1 emerging as a key protein with a likely causal role in SCAD pathogenesis. These findings highlight biological pathways for mechanistic studies and protein targets for potential therapeutic interventions.

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Publication Details

Journal
Circulation Genomic and Precision Medicine
Published
2026-01-29
DOI
https://doi.org/10.1161/circgen.125.005330
Primary Topic
Cardiovascular Issues in Pregnancy
Type
article
Field-Weighted Citation Impact
0.00
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article

Genetic Association of Circulating Proteins and Gene Transcripts With Spontaneous Coronary Artery Dissection

Rohin K. Reddy, Brian P. Halliday, Thomas R. Webb, Alice Sacco et al.
Circulation Genomic and Precision Medicine
Cardiovascular Issues in Pregnancy
article

Genetic Association of Circulating Proteins and Gene Transcripts With Spontaneous Coronary Artery Dissection

Rohin K. Reddy, Brian P. Halliday, Thomas R. Webb, Alice Sacco, J Ware, Antonio de Marvao, A. Schuermans, Martina Milani, Ania A. Baranowska-Clarke, Alec Morley, Paulene A. Quinn, David Adlam, K. H. Nicolaides, Thong Huy Cao, Leong L. Ng, Buu Truong, Adam S. Butterworth, Michael C. Honigberg
article en

Abstract

Integrative analysis of proteomic, transcriptomic, and experimental data revealed 4 circulating proteins genetically associated with SCAD risk, with ECM1 emerging as a key protein with a likely causal role in SCAD pathogenesis. These findings highlight biological pathways for mechanistic studies and protein targets for potential therapeutic interventions.

Circulation Genomic and Precision MedicineVol. 19(1)
Broad Institute (US), Harvard University (US), Imperial College Healthcare NHS Trust (GB), University of Leicester (GB), King's College London (GB), General Medical Council (GB), Royal Brompton & Harefield NHS Foundation Trust (GB), Glenfield Hospital (GB), University Hospitals of Leicester NHS Trust (GB), Harefield Hospital (GB), British Heart Foundation (GB), National Institute for Health and Care Research (GB), Massachusetts General Hospital (US), Cambridge School (PT), Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda (IT), Lung Institute (US), Nuffield Health (GB), Alessandro Manzoni Hospital (IT), Fetal Medicine Foundation (GB), Anna Needs Neuroblastoma Answers (US), MRC Biostatistics Unit (GB), Health Data Research UK (GB), Center for Systems Biology (US), Canisius College (US), Medical Research Council (GB), KU Leuven (BE)
Good health and well-being
Openalex Percentile: Top 74%
Cardiovascular Issues in Pregnancy
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