Intramuscular Adipose Tissue Accumulation is a Key Determinant of Limb Function in Peripheral Artery Disease
IMAT accumulation is a key determinant of limb function in PAD/CLTI. Our studies demonstrate that targeting IMAT formation could improve limb function in mice with experimental PAD. Together, these findings suggest that developing strategies to limit or reduce IMAT may improve limb function and walking performance in patients with PAD/CLTI, providing a novel therapeutic avenue to address a critical unmet need.
Authors
- Ambili Bai Appu
- Victoria R. Palzkill (ORCID: https://orcid.org/0000-0001-9382-169X)
- Curt D. Sigmund (ORCID: https://orcid.org/0000-0002-1453-0921)
- TERENCE EDWARD RYAN (ORCID: https://orcid.org/0000-0003-0780-029X)
- Kyoungrae Kim (ORCID: https://orcid.org/0000-0001-9513-6469)
- Caroline G. Pass (ORCID: https://orcid.org/0009-0003-4234-8777)
- Daniel Kopinke (ORCID: https://orcid.org/0000-0001-5148-8219)
- Xinyue Liu (ORCID: https://orcid.org/0000-0002-3479-4684)
- Divyansha Moparthy
- Salvatore T. Scali
- Jaewon Choi (ORCID: https://orcid.org/0009-0000-5298-4943)
- Scott A Berceli
- Qingping Yang
Institutions
- Medical College of Wisconsin (US)
- University of Florida (US)
- Malcom Randall VA Medical Center (US)
- North Florida/South Georgia Veterans Health System (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-01-29
- DOI
- https://doi.org/10.64898/2026.01.27.701833
- Primary Topic
- Peripheral Artery Disease Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00