Streptochlorin‐derived sulfonamides: discovery of novel antifungal scaffold through structural modification and <scp>SAR</scp> analysis
The 3-phenylsulfonamide-modified streptochlorin derivatives exhibited potent antifungal activity, with D35-D37 showing particular efficacy. Their successful synthesis offers a novel antifungal scaffold, while preliminary studies suggest potential cytochrome bc<sub>1</sub> complex inhibition as a mode of action. © 2026 Society of Chemical Industry.
Authors
- Qiang Sha (ORCID: https://orcid.org/0000-0002-3253-2226)
- Xiao Feng (ORCID: https://orcid.org/0000-0001-8919-6000)
- Gizachew Mulugeta Manahelohe (ORCID: https://orcid.org/0000-0002-6098-9450)
- O. Sukhbaatar
- J. Liu (ORCID: https://orcid.org/0000-0001-6948-2528)
- Feng‐Lei Duan
- Ming‐Zhi Zhang
- Yan Wang
- Yu‐Cheng Gu
- Qiang Bian
Institutions
- Nanjing Agricultural University (CN)
- Mongolian University of Life Sciences (MN)
- Nankai University (CN)
- Syngenta (United Kingdom) (GB)
- University of Gondar (ET)
- Syngenta (Switzerland) (CH)
Publication Details
- Journal
- Pest Management Science
- Published
- 2026-01-28
- DOI
- https://doi.org/10.1002/ps.70583
- Primary Topic
- Marine Sponges and Natural Products
- Type
- article
- Field-Weighted Citation Impact
- 0.00