Ultra-Widefield Fluorescein Angiographic Quantitative Leakage Parameters and Clinical Outcomes in Nonproliferative Diabetic Retinopathy

In eyes with NPDR, higher leakage at baseline and an increase from baseline to 1 year were associated with greater risk of DRSS worsening and vision-threatening complications, including VH and PDR. These findings support quantitative leakage assessment at baseline and over time as a promising biomarker for predicting the severity and progression of diabetic retinopathy.

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Publication Details

Journal
JAMA Ophthalmology
Published
2026-01-29
DOI
https://doi.org/10.1001/jamaophthalmol.2025.5658
Primary Topic
Retinal Diseases and Treatments
Type
article
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article

Ultra-Widefield Fluorescein Angiographic Quantitative Leakage Parameters and Clinical Outcomes in Nonproliferative Diabetic Retinopathy

Nicole M. Massu, Aimee M. Walker, Gina M Lester, Hannah Sheppard et al.
JAMA Ophthalmology
Retinal Diseases and Treatments
article

Ultra-Widefield Fluorescein Angiographic Quantitative Leakage Parameters and Clinical Outcomes in Nonproliferative Diabetic Retinopathy

Nicole M. Massu, Aimee M. Walker, Gina M Lester, Hannah Sheppard, Shay Bourgeois, Pat Winter, Pat A. Winter, Kristy Keller, Mark A. Peters, Kyle J. Alliman, Sandra Galusic, JoLene G. Carranza, LTC CALVIN E. MEIN, James C. Major, Leanne T. Labriola, Joseph P. Walker, Ray Kiesel, Jamin Brown, Joan DuPont, Asmita Indurkar, Lisa Bicknell, Joann Starr, Aimee Walker, Allen McKinney, Kate M McKee, Chirag P. Shah, Robbin Spivey, Ann Hoskin-Mott, Danni Liu, Jim M. Berger, Gopal Karsaliya, Twyla J Robinson, Margie Graham, Rita K. Kirby, Andrzej Kozbial, Amy M. Hutson, Paul Raskauskas, Sarah Fishbein, Sarah Oelrich, Rebecca Yee, Maturi RK, Nina Webb, Damanda F. Fagan, Michael N. Krigman, Theresa Wiens, Stephen Hobbs, L M Aiello, Bianca C Luong, Stacey Durling, Tina Seidu, Gregory M. Fox, Trina MacDonnell, Reem Amine, Stephanie L. Ho, Alyssa Baptista, Tiffany N. Ogbuewu, Maura A. Estes, L. H. Levin, Lisa M. Boender, Tlucek PS, Sonny W. Icks, Steve Carlton, Kelly Avery, Debra Ann Cantrell, Kemi Adeyemo, Phillip Le, John Grybas, Sadia Y Karani, Stacy M. Supapo, Valerie Gatavaski, Isaac A Kotei, Brian S Puckett, Katie Milstead, Romesh Babaria, Tamara L Dodel, Teneisha A. Ragin, Inessa M Flato, Luann Wiechelt, Samantha Jacobo, Prof. Sarah Ennis, Ren Yong, Yin C. Chen, Wai Kit Wong, Tori Moore, Ian E. Brown, Angela S. Martin, Susan P. Herder, Colin Ma, Henry A. Leder, Kiersten Bruce, Jan Ulrich, Brenda L. Hunter, Shireen Glynn, Luis R. Salinas, Brook Parsons, Monica D. Nayar, Grant M. Comer, Kevin I. Rosenberg, Mohamed Ashraf Elmasry, Khoi Tran, Christine Ringrose, Adrienne C Swann, Anne Marie Godfrey, Michelle Moon, Miranda F James, Marc E. Thomas, Jeffrey P Barker, Jennifer K. Sun, Danielle Dyshanowitz, Veronica A. Sneed, Lisa M Wolff, Laurie J. Sienkiewycz, Jeff Wheeler, Uma M. Balasubramaniam, Bryan Harrison, Ivan R. Batlle, Garnet Louise Elvena, A. Thomas Ghuman, Melina Vela, Kumar Sambhav, Alessandro A. Castellarin, Michelle L. Manley, Jenna T. Herby, Sonya L Alcaraz, Farzin Forooghian, Russ Burris, Amy L Ford, Bilgin Turhal, Dennis P. Han, Dante J. Pieramici, Glenn J. Jaffe, Sean Grout, Anita H. Leslie, Ceara L Wendel, Mitzi Hynes, Tametha Johnson, Lynn M. Kwasniewski, Judy E. Kim, Kakarla V. Chalam, JoAnn T Booth, Thu P. Vu, Cory Mangham, Steve L. Papaconstantinou, Jeanne Van Arsdall, Vanessa A. Bergman, Len Richine, Claire T. Calhoun, Chris A. Montesclaros, Andrea Dean, Adam R. Glassman, Megan Allis, Ghulam Shabbir Hamdani, Brandon S Gardner, Lisa Lovelady, Eduardo Vitor Navajas, Daniela Mariel Wilson, Jie Sun, Lexie R. Ainley, Christopher M. Brown, III Frederick L. Ferris, Tiffany R. Swinford, Cheryl L White, Jonathan San Roman, Kimberly A. Williamson, Ashish G. Sharma, Carrie D Tessau, Margaret E Charpentier, Vicki Barwick, Patricia Coppola, Nick Rhoton, Jae W Rhee, Moises A. Chica, Harinderjit Singh, Matthew S. Benz, Houston P Sharpe, Mary Frey, Nubia Landaverde, Michele Woodward, Alan F. Cruess, Mark Janowicz, Brenda Rodriquez, David Emmert, Bob Moore, Erika Nelson, Brittany A Murphy, David M. Brown, Eileen E. Tonner, Kylie S. Sedberry, Christine Morrison, Glenn Wing, William Carli, Szilard Kiss, Tori Moore, R. Keith Shuler, Alisha N Brewer, Sara Freeman, Ashley M Adamo, Daniel F. Martin, Marriner L. Altmann, Felix N. Sabates, Kayla A Bratcher, Eric Chen, Sarah L Berlatsky, Lindsay Allison Foster, Lauren Brandt, Jack Bowers, Joseph R. Beringer, Mara Goldberg, Mary K. Monk, Ilsa Ortega, Eleanor Dorsey, Jared S. Nielsen, Bharani Krishna Mynampati A, Tom Reeves, John A. Wells, Omar S. Punjabi, Rita K. Kirby, Stephanie J Moebius, Stefanie R. DeSantis, Kimberly Hosein, Cassandra J. Barnhart, Carol A Shore, Tami Jo Woehl, Cynthia R. Stockdale, Paolo S. Silva, Bradley A. Stern, Spencer D Ridgway, Elizabeth S. Weimann, Elizabeth Quellar, DRCR Retina Network, Kristin Josic, Sabera T. Shah, Deborah M. Cadwell, Mathew W. MacCumber, Richard H. Fish, Catherine Carroll, Sheri Drossner, Negin Atri, Tyneisha McCoy, Peggy R Orr, Marilyn A. Johnson, Raymond K. Kiesel, Ryan M. Reid, David A.L. Maberley, Carmen M. Valenzuela-Silva, Pradeepa Yoganathan, Angela N. Palacios, Paula A. Johnson, Ashley M. Metzger, Thomas B. Connor, Marcia Niec, Britney Meadows, Lisa A. Jackson, Marianne Parker, Amina Farooq, R. Rishi Gupta, Ankoor R. Shah, Deborah Donohue, David Browning, Michelle Moon, Beau A Richter, Angella K. Gentile, Laura J. Hall, Nader Moinfar, Samantha Kettler, Angela K. Price, Jamie Spillman, Dennis Cain, Lynnette F. Lambert, Natasa Stankovic, Ashley M. Harless, Lydia Adams, Lynn Watson, Alesia K McCalla, Julianne Vitale-Kuhn, Krystal Nikki Holmes, Luann Wiechelt, Karen L Seyez, Brian B. Dale, Dara Dombrowski, Roy W. Beck, Carl W. Baker, Barbara A. Blodi, Ashley Studebaker, Steve Morris, Angela Chang, Lisa Spuches, Diana Rodriguez, David Garcia, Michael D. McOwen, Christopher Sean Wienecke, Heather Koger-Grifaldo, Gina Hong, G. Robert Hampton, Margaret E. Stockman, Christina Y. Weng, Brenda Nakoski, Robert W. Wong, Lauren A Talasnik, Sara L Cloudt, Meredith Berry, William J. Wirostko, Keven W Lunsford, Konstantina Sampani, Amber R VandeVelde, Kyle J. Alliman, Sarah Kociborski, Paul Andrew Edwards, Justin Walsh, Raul E. Lince, Kisung Woo, Cary A. Stoever, Marco A Munoz, John Grybas, David J Clark, Karen Matar, Darrell Baskin, Olivera Sutakovic, Siobhan O. Ortiz, Amy C. Schefler, Dinah S Oude-Reimerink, Dallas R. Sandler, Katie M. Ventimiglia, Ashley Hughes, Meagan Huggins, Brenda J. Bobbitt, Sandeep Grover, Jazzmin N Smith, John F. Payne, Belinda A. Almanza, Taryn F. Boisvert, Vinay A. Shah, Linette Miranda, Nicholas G. Anderson, Susan Bressler, Pualani Smith, Kristina Oliver, Autumn K. Finch, James Miller, Abla M Harara, Joshua Cohen, Courtney Nichole Lenane, Jerry D. Cavallerano, Sijia Cao, Catherine Damron, Bryan Noel, Elizabeth L. DuBose, Lina Chen, Shannon R. Almeida, Anton Orlin, Matthew Giust, Donna McClain, Kanika A Bhansali, Mira Jovanovic, Crystal A. Franklin, Apurva K. Patel, Jil D Baker, Christina J. Fleming, Jennifer L. Kruger, Tiara L. Reed, Amber N Irons, Seema Garg, Jennifer L. Simmons, Nickolas Chen, Jennifer L. Belz, Alexander J. Brucker, Brittany Rego, Daniel Park, Rosa Y. Kim, David Albiani, Dominique Cammarata, Eileen Knips, Abigail Miller, Sandra L. Boglione, Paula L Bix, Ronald M. Kingsley, Courtney Mahr, Alecia B. Camp, Christine Hoerner, Jay Rostvold, Shannon M Rehling, Jim M. Berger, Carin M. Preston, Lauren D. Ukleya, Tracey M. Caldwell, Chirag D. Jhaveri, Celia E Benvenutti, Gowtham Jonna, Terri Cain, Margaret J. Orr, Paul G. Arrigg, Edward A Slade, Felix Y. Chau, Jaynee Baker, Carla Edwards, Julie Asher, Lindsey Colegrove, Michelle Buck, Yin C. Chen, Emily Y. Chew, Ken Ivey, Sharon R. Constantine, Simone S. Dupre, Sherry L. Fredenberg, Wei Tian, Lee M. Jampol, Boris Corak, Kenneth R. Diddie, Deborah K. Schlossman, Amy Thompson, Hanna Kwak, Charlotte Harris, Tiffany M Carter, Lindsay Burt, Blanca Ornelas, Pamela V. Singletary, Anne-Marie Godfrey, Thomas Bailey, Whitney Stonewall, Andrew J. Barkmeier, Jennifer I. Lim, Aleksandra Kuzmanovic
article en

Abstract

In eyes with NPDR, higher leakage at baseline and an increase from baseline to 1 year were associated with greater risk of DRSS worsening and vision-threatening complications, including VH and PDR. These findings support quantitative leakage assessment at baseline and over time as a promising biomarker for predicting the severity and progression of diabetic retinopathy.

JAMA OphthalmologyVol. 144(3)
Joslin Diabetes Center (US), Universitas Jambi (ID), Emory Eye Center (US), Jaeb Center for Health Research (US), Cleveland Eye Clinic (US)
Good health and well-being
Openalex Percentile: Top 74%
Retinal Diseases and Treatments
DOIOpen Access PDFOpenAlex
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