Antinuclear antibody targets in autoimmune hepatitis and drug-induced liver injury: Diagnostic relevance of nucleosome antibodies

In ANA-positive patients with a homogeneous ANA pattern, anti-nucleosome antibodies provide high diagnostic accuracy in distinguishing AIH from DILI. These findings suggest that anti-nucleosome antibodies may aid in the diagnostic workup of ANA-positive liver injury.

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Publication Details

Journal
Journal of Translational Autoimmunity
Published
2026-01-29
DOI
https://doi.org/10.1016/j.jtauto.2026.100354
Primary Topic
Liver Diseases and Immunity
Type
article
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article

Antinuclear antibody targets in autoimmune hepatitis and drug-induced liver injury: Diagnostic relevance of nucleosome antibodies

Michael Nagler, Juliette Schlatter, Henning Nilius, M P Horn et al.
Journal of Translational Autoimmunity
Liver Diseases and Immunity
article

Antinuclear antibody targets in autoimmune hepatitis and drug-induced liver injury: Diagnostic relevance of nucleosome antibodies

Michael Nagler, Juliette Schlatter, Henning Nilius, M P Horn, Michèle Freiburghaus, N. Semmo, M. Kolev, Guido Stirnimann, Martin Wartenberg
article en

Abstract

In ANA-positive patients with a homogeneous ANA pattern, anti-nucleosome antibodies provide high diagnostic accuracy in distinguishing AIH from DILI. These findings suggest that anti-nucleosome antibodies may aid in the diagnostic workup of ANA-positive liver injury.

Journal of Translational AutoimmunityVol. 12
University of Bern (CH), University Hospital of Bern (CH)
Good health and well-being
Openalex Percentile: Top 71%
Liver Diseases and Immunity
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