The qEEG-TIPS score: Development of a predictive model for recurrent overt hepatic encephalopathy after elective TIPS

Recurrent overt hepatic encephalopathy (OHE) is the primary complication of transjugular intrahepatic portosystemic shunt (TIPS) in patients with cirrhosis, markedly reducing quality of life, increasing healthcare burden, and complicating clinical decision-making. This study introduces and internally validates the qEEG-TIPS score, a novel, non-invasive tool integrating quantified electroencephalography with clinical variables to predict the short-term risk of recurrent OHE after elective TIPS. These findings hold particular relevance for patients, hepatologists, and transplant teams as they enable more personalized risk assessment prior to TIPS and may guide decisions on prophylaxis, patient selection, and post-procedural monitoring. If externally validated, the qEEG-TIPS score could enhance clinical pathways by identifying high-risk patients for targeted interventions, supporting more cost-effective and patient-centered TIPS management strategies.

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Publication Details

Journal
JHEP Reports
Published
2026-01-29
DOI
https://doi.org/10.1016/j.jhepr.2026.101753
Primary Topic
Liver Disease and Transplantation
Type
article
Field-Weighted Citation Impact
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article

The qEEG-TIPS score: Development of a predictive model for recurrent overt hepatic encephalopathy after elective TIPS

Fabiola Milosa, Alberto Zanetto, Francesco Ascari, M. Scoppettuolo et al.
JHEP Reports
Liver Disease and Transplantation
article

The qEEG-TIPS score: Development of a predictive model for recurrent overt hepatic encephalopathy after elective TIPS

Fabiola Milosa, Alberto Zanetto, Francesco Ascari, M. Scoppettuolo, Federico Casari, Marcello Bianchini, Melania Gaggini, Antonio Colecchia, Lisa Zarantonello, Filippo Scianò, Dario Saltini, Cristian Caporali, Rosina Maria Critelli, Tomas Guasconi, Filippo Schepis, Andrea Salome Velasco Mayorga, Francesco Vizzutti, Antonio Piscopo, Sara Montagnese
article en

Abstract

Recurrent overt hepatic encephalopathy (OHE) is the primary complication of transjugular intrahepatic portosystemic shunt (TIPS) in patients with cirrhosis, markedly reducing quality of life, increasing healthcare burden, and complicating clinical decision-making. This study introduces and internally validates the qEEG-TIPS score, a novel, non-invasive tool integrating quantified electroencephalography with clinical variables to predict the short-term risk of recurrent OHE after elective TIPS. These findings hold particular relevance for patients, hepatologists, and transplant teams as they enable more personalized risk assessment prior to TIPS and may guide decisions on prophylaxis, patient selection, and post-procedural monitoring. If externally validated, the qEEG-TIPS score could enhance clinical pathways by identifying high-risk patients for targeted interventions, supporting more cost-effective and patient-centered TIPS management strategies.

JHEP ReportsVol. 8(4)
University of Modena and Reggio Emilia (IT), University of Padua (IT), Istituto di Fisiologia Clinica (IT), Azienda Ospedaliero-Universitaria di Modena (IT), Azienda Ospedaliero-Universitaria Careggi (IT), National Research Council (IT)
Reduced inequalities
Openalex Percentile: Top 71%
Liver Disease and Transplantation
DOIOpen Access PDFOpenAlex
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