Biocompatibility and Inflammatory Pathways of Silicone Oil in Complex Retinal Detachment: An in vitro and Clinical Study
Eyes with complex RRD exhibit a sustained pro-inflammatory and pro-fibrotic microenvironment within the perisilicone compartment, independent of tamponade duration. Proteins, particularly albumin, appear to act as key biological surfactants linking inflammation to SO emulsification. These findings highlight the need for targeted anti-inflammatory and anti-fibrotic strategies, as well as standardized tools for detecting subclinical emulsification.
Authors
- Francisco Javier Valentín Bravo
- Reinaldo Vallejo (ORCID: https://orcid.org/0000-0002-9689-5974)
- Nadia Galindo Cabello
- Tomás Rechi-Sierra
- Carlos Marques Neves
- Tatsiana Stalmashka
- Ricardo Usategui-Martín
- Elisa Julião-Campos
- Cristina Andrés Iglesias
- Rosa Lomelino-Pinheiro
- Eva María Sobas Abad
- Pablo Redruello-Guerrero
Institutions
- Universidad de Valladolid (ES)
- Unidad de Investigación en cuidados y servicios de salud (Investén-isciii) (ES)
- Research Institute of Health Sciences (ES)
- Instituto de Biomedicina y Genética Molecular de Valladolid (ES)
- Hospital de Santa Maria (PT)
- Hospital Clínico Universitario de Valladolid (ES)
- Complejo Asistencial Universitario de Palencia (ES)
- University of Coimbra (PT)
Publication Details
- Journal
- Ophthalmologica
- Published
- 2026-01-29
- DOI
- https://doi.org/10.1159/000550687
- Primary Topic
- Retinal and Macular Surgery
- Type
- article
- Field-Weighted Citation Impact
- 0.00