Sex-specific cardioprotective role of miR-30a-5p through estrogen-dependent mechanisms in a mouse model of heart failure
These findings establish miR-30a-5p as a crucial sex-specific regulator of HF (mainly HFpEF), operating through estrogen signaling to balance cardiac compliance and metabolic adaptation.
Authors
- Jiafeng Chen (ORCID: https://orcid.org/0000-0002-1088-5338)
- Xiaocheng Zhang (ORCID: https://orcid.org/0000-0001-7532-9570)
- Minxue Quan
- Guo Fu
- Shiyao Zhang (ORCID: https://orcid.org/0000-0002-7640-6045)
- Ruiying Wang
- Le Zhang
- Gang Li
- Li-Qing Yu
Institutions
- Xiamen University (CN)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2026-01-29
- DOI
- https://doi.org/10.1186/s12933-026-03090-7
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00