Molecular evidence associating GLP-1 receptor agonists and brain-derived neurotrophic factors in neurodegenerative and psychiatric disorders: A systematic review
GLP-1RAs upregulate BDNF in preclinical models, supporting its role as a key mediator of neuroprotection. Despite some BDNF-independent actions, the consistent restoration of neurotrophic support positions BDNF as a central pathway for disease modification.
Authors
- Yang Jing Zheng
- Christine E. Dri
- Gia Han Le
- Kayla M. Teopiz
- Xin Tong Zhou
- Roger S. McIntyre
- Tianyi Xu
- Sabrina Wong
Institutions
- University of Toronto (CA)
- Brain and Cognition Discovery Foundation (CA)
Publication Details
- Journal
- Asian Journal of Psychiatry
- Published
- 2026-01-29
- DOI
- https://doi.org/10.1016/j.ajp.2026.104870
- Primary Topic
- Nerve injury and regeneration
- Type
- article
- Field-Weighted Citation Impact
- 0.00