Abstract TP241: Redefining Ischemic Core, Penumbra, and Target Mismatch on CT Perfusion in Acute Anterior Distal Medium Vessel Occlusions

Background: Recent trials of endovascular thrombectomy (EVT) for acute distal medium vessel occlusions (DMVOs) were negative but also used inconsistent imaging-based inclusion criteria, whereas many successful large vessel occlusion (LVO) EVT trials used empirically validated CT perfusion-based target mismatch (TMM) criteria: an ischemic penumbra (time-to-maximum [Tmax] >6s) to core (relative cerebral blood flow [rCBF] <30%) mismatch ratio (MMR) ≥1.8 and volume (MMV) ≥15mL. We aimed to determine optimal corresponding definitions in DMVOs to improve patient selection for EVT. Methods: We retrospectively analyzed patients with acute anterior DMVOs from prospectively collected databases at four comprehensive stroke centers. To assess core, we evaluated how well pretreatment rCBF <20%, <30%, <34%, and <38% volumes correlated with MRI-based posttreatment follow-up volumes (FIVs) in successfully recanalized patients. To evaluate penumbra, we assessed how well pretreatment Tmax >4s, >6s, >8s, and >10s volumes correlated with FIVs in unrecanalized patients. Then, we evaluated whether these improved parameters for core and penumbra better quantified LVO TMM and identified an optimal DMVO TMM definition. Results: In 122 core patients, rCBF <38% most strongly correlated with FIVs (concordance correlation coefficient [CCC] 0.30 [95% CI, 0.15-0.48]), outperforming rCBF <30% (CCC 0.21 [0.10-0.35]) (p < 0.001). In 70 penumbra patients, Tmax >8s most strongly correlated with FIVs (CCC 0.49 [0.25-0.77]), outperforming Tmax >6s (CCC 0.39 [0.17-0.68]) (p < 0.001). In 180 patients undergoing EVT with Tmax >6s to rCBF <30% MMR ≥1.8 and MMV ≥15mL, recomputing MMR and MMV using Tmax >8s and rCBF <38% further separated those with favorable outcomes (p = 0.007). In the same cohort, Tmax >8s to rCBF <38% MMR ≥2.2 and MMV ≥10mL maximized the number of patients benefitted (p < 0.001, absolute risk reduction 26%). Conclusions: In acute anterior DMVOs, rCBF <38% and Tmax >8s best correspond to ischemic core and penumbra, respectively; more favorably quantify LVO TMM, and reveal optimal TMM criteria. These results should be prospectively investigated as inclusion criteria for EVT in this population and suggest recent negative DMVO EVT trials may have been confounded by suboptimal patient selection.