Combining Intranasal Esketamine and Electroconvulsive Therapy in Severe Treatment‑Resistant Depression
In this naturalistic series, combined ECT+ESK was feasible and associated with sustained symptom improvement, wider ECT spacing, and potentially lower cognitive burden. Findings are hypothesis-generating, support prospective controlled trials to define sequencing, dosing, and safety.
Authors
- Pino Alonso
- J. Menchón
- Mikel Urretavizcaya (ORCID: https://orcid.org/0000-0003-1880-5731)
- S. López-Rodríguez
- Aida de Arriba-Arnau
Institutions
- Instituto de Salud Carlos III (ES)
- Bellvitge University Hospital (ES)
- Institut d'Investigació Biomédica de Bellvitge (ES)
- Centro de Investigación Biomédica en Red de Salud Mental (ES)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- Journal of Ect
- Published
- 2026-01-29
- DOI
- https://doi.org/10.1097/yct.0000000000001233
- Citations
- 1
- Primary Topic
- Treatment of Major Depression
- Type
- article
- Field-Weighted Citation Impact
- 32.57