Glial Cells as Central Players in Neuroinflammation and Neuronal Damage Caused by Bacterial Pneumonia
Recent studies have demonstrated that regulating microglial and astrocytic hyperactivation can attenuate the inflammatory response. Therefore, targeting glial cells during SAE holds significant therapeutic potential, offering a promising avenue for the development of new strategies aimed at reversing the exacerbated CNS inflammatory response, mitigating neuronal damage, and ultimately reducing the long-term neurological sequelae observed in post-septic patients.
Authors
- Cassiano Felippe Gonçalves-de-Albuquerque (ORCID: https://orcid.org/0000-0002-4458-3055)
- Adriana Ribeiro Silva (ORCID: https://orcid.org/0000-0002-5137-4251)
- Marina Ferreira-Costa
- Aléxia M. S. Ferreira
- Léo Victor G. Castro
Institutions
- Universidade Federal do Rio de Janeiro (BR)
- Universidade Federal Fluminense (BR)
- Fundação Oswaldo Cruz (BR)
- Universidade Federal do Estado do Rio de Janeiro (BR)
Publication Details
- Journal
- NeuroImmunoModulation
- Published
- 2026-01-29
- DOI
- https://doi.org/10.1159/000550709
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
- Fundação Oswaldo Cruz
- Universidade Federal do Estado do Rio de Janeiro