Hepatoprotective iridoid glycosides from the aerial parts of <i>Paederia foetida</i>

Two previously undescribed iridoid glycosides, paedoside I (<b>1</b>) and paedoside J (<b>2</b>), were isolated from the aerial parts of <i>Paederia foetida.</i> The structures of these compounds, especially their absolute configurations, were elucidated by comprehensive spectroscopic analysis and chemical methods. Compounds <b>1</b> and <b>2</b> were tested for cytotoxicity, hepatoprotective activity, and inhibitory effects on NO production in LPS-activated microglia, and <b>2</b> exhibited hepatoprotective activity against N-acetyl-<i>p</i>-aminophenol (APAP)-induced HepG2 cell damage.