Asymmetric Aerobic Intramolecular Dearomative <i>ortho</i> Coupling of Tethered Phenols by Chromium-Salen Complex/Nitroxyl Radical Catalysis
Herein, we report the catalytic asymmetric intramolecular dearomative coupling of tethered phenols in ortho-para fashion under aerobic conditions. Cooperative catalysis with a chromium-salen complex/nitroxyl radical enabled the desired transformation to proceed at ambient temperature under oxygen atmosphere. A range of tethered phenols were efficiently converted into spirocyclic 2,4-dienones in moderate to good yields and enantioselectivities (up to 68% enantiomeric excess (ee)).
Authors
- Yusuke Sasano (ORCID: https://orcid.org/0000-0002-3852-8607)
- Shogo Fujiki
- Y. Iwabuchi
- Nao Yokota
- Shota Nagasawa
Institutions
- Tohoku University (JP)
Publication Details
- Journal
- Chemical and Pharmaceutical Bulletin
- Published
- 2026-01-29
- DOI
- https://doi.org/10.1248/cpb.c25-00762
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Agency for Medical Research and Development
- Shorai Foundation for Science and Technology
- Japan Society for the Promotion of Science