Odaph Promotes Osteoblast Proliferation and Differentiation by Targeting the AMPK/mTOR Signaling Axis to Activate Autophagy

Odaph enhances osteoblast function through autophagy induction mediated by the AMPK/mTOR axis. These results reveal a new regulatory mechanism in bone biology and indicate that Odaph could serve as a potential therapeutic target for maxillofacial bone conditions, including jaw osteopenia and periodontal bone loss.

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Publication Details

Journal
Frontiers in Bioscience-Landmark
Published
2026-01-14
DOI
https://doi.org/10.31083/fbl45855
Primary Topic
Autophagy in Disease and Therapy
Type
article
Field-Weighted Citation Impact
0.00
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article

Odaph Promotes Osteoblast Proliferation and Differentiation by Targeting the AMPK/mTOR Signaling Axis to Activate Autophagy

Y N Wang, Haiyu Mu, Xu Zhenzhen, Qing Chu et al.
Frontiers in Bioscience-Landmark
Autophagy in Disease and Therapy
article

Odaph Promotes Osteoblast Proliferation and Differentiation by Targeting the AMPK/mTOR Signaling Axis to Activate Autophagy

Y N Wang, Haiyu Mu, Xu Zhenzhen, Qing Chu, Haitao Qu, Yao Lin, Wenyu Guo, Guolei Zhu
article en

Abstract

Odaph enhances osteoblast function through autophagy induction mediated by the AMPK/mTOR axis. These results reveal a new regulatory mechanism in bone biology and indicate that Odaph could serve as a potential therapeutic target for maxillofacial bone conditions, including jaw osteopenia and periodontal bone loss.

Frontiers in Bioscience-LandmarkVol. 31(1)
Shandong University of Aeronautics (CN), Yuhuangding Hospital (CN), Jinan Stomatological Hospital (CN)
Openalex Percentile: Top 73%
Autophagy in Disease and Therapy
DOIOpen Access PDFOpenAlex
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Odaph Promotes Osteoblast Proliferation and Differentiation by Targeting the AMPK/mTOR Signaling Axis to Activate Autophagy — Y N Wang, Haiyu Mu, et al. · Frontiers in Bioscience-Landmark (2026) | TGRS Research Map | TGRS