Postmortem Associations Between Alzheimer Disease Pathology and Plasma pTau217, GFAP, and NfL in AD and AD-Related Dementias
Plasma pTau217, but not GFAP or NfL, levels accurately reflect the presence of ADNC in the brain even in individuals with an NPDx1 of a non-AD dementia. Thus, a positive plasma pTau217 test in an individual with a suspected non-AD dementia should not necessarily be considered a misdiagnosis of the presumed non-AD dementia or as a false positive, but rather as evidence of ADNC copathology.
Authors
- Chenyan Wu (ORCID: https://orcid.org/0000-0002-8456-3825)
- Hadia Fatima
- Taron Gorham
- S. R. Arnold (ORCID: https://orcid.org/0000-0002-4881-5685)
- Jacob N. Wohlstadter (ORCID: https://orcid.org/0009-0000-4467-6895)
- Daniel Romero (ORCID: https://orcid.org/0000-0003-1505-3247)
- Molly Weik
- Catherine Demos (ORCID: https://orcid.org/0000-0003-3914-1954)
- Teresa Gómez‐Isla (ORCID: https://orcid.org/0000-0002-7977-2075)
- Derek H. Oakley (ORCID: https://orcid.org/0000-0002-6998-9510)
- Pia Kivisäkk
- Lori B. Chibnik
- Hiroko Dodge
- George Sigal
- Nikhil Padmanabhan
- Bradley T. Hyman
- Deborah L. Blacker
- Matthew P. Frosch
- Sudeshna Das
Institutions
- Harvard University (US)
- Yale University (US)
- Massachusetts General Hospital (US)
- Alzheimer’s Disease Neuroimaging Initiative (US)
- Meso Scale Discovery (United States) (US)
Publication Details
- Journal
- Neurology
- Published
- 2026-01-29
- DOI
- https://doi.org/10.1212/wnl.0000000000214351
- Citations
- 1
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 32.84