Downregulation of Cyclin Kinase Inhibitors p16 <sup>INK4a</sup> and p27 in Conjunctival Melanomas
p16INK4a and p27 are significantly downregulated in CJM and may help in the histopathological differential diagnosis between melanoma and conjunctival nevus. p16INK4a loss involves genomic, epigenetic, and post-translational mechanisms. Restoring p16 function may reduce CJM aggressiveness.
Authors
- Nicolò Riggi (ORCID: https://orcid.org/0000-0001-9160-1984)
- Adeline Berger (ORCID: https://orcid.org/0000-0003-2986-4489)
- Ann Schalenbourg
- Katya Nardou
- Alexandre Moulin
- Emérentienne Sarrasin
- Elifnaz Çelik (ORCID: https://orcid.org/0000-0002-0324-5228)
- Carlo Rivolta
- Elea Lalys
Institutions
- University of Leicester (GB)
- University of Basel (CH)
- University Hospital of Basel (CH)
- Institute of Molecular and Clinical Ophthalmology Basel (CH)
- University of Lausanne (CH)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2026-01-29
- DOI
- https://doi.org/10.1167/iovs.67.1.59
- Primary Topic
- Ocular Oncology and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00