EBV Dysregulation Is Associated With Immune Imbalance in Multiple Sclerosis
Our findings support the hypothesis that EBV latency disruption and lytic reactivation contribute to immune dysregulation in MS. The association between EBV transcriptional activity and immune gene alterations may uncover potential peripheral biomarkers of EBV-driven pathology. These molecular signatures may provide insights into novel therapeutic avenues and peripheral biomarkers for MS monitoring.
Authors
- Cristina Mancosu
- Pankaj Trivedi (ORCID: https://orcid.org/0000-0001-9574-6304)
- Caterina Veroni (ORCID: https://orcid.org/0000-0002-6043-1051)
- Serena Martire (ORCID: https://orcid.org/0000-0001-6889-888X)
- Paola Valentino
- Fabiana Marnetto
- Lucia Benincasa
- Chiara Meloni
- C. Fagnani
- Jessica Frau
- Alessia Di Sapio
- Clara Ballerini
- Diletta Galano
- Antonio Bertolotto
Institutions
- University of Cagliari (IT)
- Istituto Superiore di Sanità (IT)
- Neuroscience Institute (IT)
- Ospedale Koelliker (IT)
- A. O. Ordine Mauriziano di Torino (IT)
- Ospedale San Luigi Gonzaga (IT)
- University of Florence (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Neurology Neuroimmunology & Neuroinflammation
- Published
- 2026-01-29
- DOI
- https://doi.org/10.1212/nxi.0000000000200545
- Primary Topic
- Viral Infections and Immunology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00