A Key Regulator of Dendritic Morphology in Supragranular Neocortex Impacts Mismatch Negativity
These results highlight alterations in higher-level sensory cortical integration in <i>Kalrn</i>-PT mice and demonstrate that adolescent-onset, disease-relevant structural and functional phenotypes can be linked by a common upstream effector. Further, these alterations appear restricted to supragranular layers, demonstrating an outsized role for <i>Kalrn</i>, particularly longer isoforms, in superficial neocortex.
Authors
- Jordan M. Ross (ORCID: https://orcid.org/0000-0003-4345-0135)
- R. D. Sweet
- Melanie Grubisha (ORCID: https://orcid.org/0000-0002-2494-6103)
- Connor G. Gallimore (ORCID: https://orcid.org/0000-0003-3531-4213)
- Valentina J. Sutton
- Anna M Rader Groves
- Jordan P Hamm
Institutions
- Nathan Kline Institute for Psychiatric Research (US)
- University of Pittsburgh (US)
- Georgia State University (US)
- New York University (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-01-28
- DOI
- https://doi.org/10.64898/2026.01.28.702244
- Primary Topic
- Neuroscience and Music Perception
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health