Clinochinsaponin A, a triterpenoid saponin from the aerial parts of <i>Clinopodium chinense</i>

A new triterpenoid saponin, 3β,16β,23α,28β-tetrahydroxyoleana-11,13(18)- dien-30β-oic acid-3-[β-D-glucopyranosyl-(1→2)]-[β-D-glucopyranosyl-(1→3)]-β-D- fucopyranoside, which was named clino-chinsaponin A (<b>1</b>), together with three known compounds, namely clinoposaponin D (<b>2</b>), naringenin (<b>3</b>), and narirutin (<b>4</b>), were isolated from <i>Clinopodium chinense</i> (Benth.) Kuntze. The structural assignments for the isolated compounds were elucidated by analysis of NMR data, and by comparison of the acquired spectroscopic data with values reported in the literature. Moreover, compounds <b>1</b>, <b>2</b>, and <b>4</b> were tested against five bacterial strains (Gram-positive and Gram-negative). Among them, compound <b>1</b> showed weak antibacterial activity against <i>Pseudomonas aeruginosa</i>.

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Publication Details

Journal
Natural Product Research
Published
2026-01-29
DOI
https://doi.org/10.1080/14786419.2026.2623205
Primary Topic
Natural product bioactivities and synthesis
Type
article
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article

Clinochinsaponin A, a triterpenoid saponin from the aerial parts of Clinopodium chinense

Bai‐Bo Xie, Dongying Zhao, Wen-Peng Yuan, Wan-shan Chen et al.
Natural Product Research
Natural product bioactivities and synthesis
article

Clinochinsaponin A, a triterpenoid saponin from the aerial parts of Clinopodium chinense

Bai‐Bo Xie, Dongying Zhao, Wen-Peng Yuan, Wan-shan Chen, Xin-yu Zang, Xin-hua Hu, Jing Hu
article en

Abstract

A new triterpenoid saponin, 3β,16β,23α,28β-tetrahydroxyoleana-11,13(18)- dien-30β-oic acid-3-[β-D-glucopyranosyl-(1→2)]-[β-D-glucopyranosyl-(1→3)]-β-D- fucopyranoside, which was named clino-chinsaponin A (<b>1</b>), together with three known compounds, namely clinoposaponin D (<b>2</b>), naringenin (<b>3</b>), and narirutin (<b>4</b>), were isolated from <i>Clinopodium chinense</i> (Benth.) Kuntze. The structural assignments for the isolated compounds were elucidated by analysis of NMR data, and by comparison of the acquired spectroscopic data with values reported in the literature. Moreover, compounds <b>1</b>, <b>2</b>, and <b>4</b> were tested against five bacterial strains (Gram-positive and Gram-negative). Among them, compound <b>1</b> showed weak antibacterial activity against <i>Pseudomonas aeruginosa</i>.

Natural Product Research
Tianjin University of Traditional Chinese Medicine (CN), Beijing VDJBio (China) (CN), National Institutes of Pharmaceutical Research and Development (China) (CN), Innovative Clinical Research (US), Shenzhen Second People's Hospital (CN)
Life in Land
Openalex Percentile: Top 74%
Natural product bioactivities and synthesis
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Clinochinsaponin A, a triterpenoid saponin from the aerial parts of <i>Clinopodium chinense</i> — Bai‐Bo Xie, Dongying Zhao, et al. · Natural Product Research (2026) | TGRS Research Map | TGRS