Clinochinsaponin A, a triterpenoid saponin from the aerial parts of <i>Clinopodium chinense</i>
A new triterpenoid saponin, 3β,16β,23α,28β-tetrahydroxyoleana-11,13(18)- dien-30β-oic acid-3-[β-D-glucopyranosyl-(1→2)]-[β-D-glucopyranosyl-(1→3)]-β-D- fucopyranoside, which was named clino-chinsaponin A (<b>1</b>), together with three known compounds, namely clinoposaponin D (<b>2</b>), naringenin (<b>3</b>), and narirutin (<b>4</b>), were isolated from <i>Clinopodium chinense</i> (Benth.) Kuntze. The structural assignments for the isolated compounds were elucidated by analysis of NMR data, and by comparison of the acquired spectroscopic data with values reported in the literature. Moreover, compounds <b>1</b>, <b>2</b>, and <b>4</b> were tested against five bacterial strains (Gram-positive and Gram-negative). Among them, compound <b>1</b> showed weak antibacterial activity against <i>Pseudomonas aeruginosa</i>.
Authors
- Bai‐Bo Xie (ORCID: https://orcid.org/0000-0002-4299-6622)
- Dongying Zhao (ORCID: https://orcid.org/0000-0001-6740-7196)
- Wen-Peng Yuan
- Wan-shan Chen
- Xin-yu Zang
- Xin-hua Hu
- Jing Hu
Institutions
- Tianjin University of Traditional Chinese Medicine (CN)
- Beijing VDJBio (China) (CN)
- National Institutes of Pharmaceutical Research and Development (China) (CN)
- Innovative Clinical Research (US)
- Shenzhen Second People's Hospital (CN)
Publication Details
- Journal
- Natural Product Research
- Published
- 2026-01-29
- DOI
- https://doi.org/10.1080/14786419.2026.2623205
- Primary Topic
- Natural product bioactivities and synthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00