Cerebral Amyloid Angiopathy Imaging Markers, Radiological Boston Criteria, and Thrombolysis Outcomes in Ischemic Stroke
In thrombolyzed patients with acute ischemic stroke, cortical superficial siderosis burden is strongly and consistently associated with higher risk of severe hemorrhage, disability, and death, making it a particularly relevant CAA marker when weighing thrombolytic risk versus benefit. Meeting radiological Boston criteria, versions 1.0 or 1.5, increases hemorrhagic risk, but meeting the latest 2.0 criteria does not.
Authors
- William Betzner (ORCID: https://orcid.org/0000-0002-9071-0705)
- Michel Christopher Frank Shamy (ORCID: https://orcid.org/0000-0002-0085-6816)
- Federico Carpani (ORCID: https://orcid.org/0000-0003-4696-5994)
- Fouzi Bala
- Kaden Lam (ORCID: https://orcid.org/0000-0002-6774-1167)
- Tolulope T. Sajobi (ORCID: https://orcid.org/0000-0002-5696-5552)
- Julia J. Hopyan
- Dar Dowlatshahi (ORCID: https://orcid.org/0000-0003-1379-3612)
- Shahab Marzoughi (ORCID: https://orcid.org/0009-0000-0416-5812)
- Gary Hunter
- Ibrahim Alhabli
- Luciana Catanese
- Nishita Singh
- Aleksandra Pikula
- Aleksander Tkach
- Aravind Ganesh
- Bijoy K. Menon
- Richard H. Swartz
- Mohammed A. Almekhlafi
- Mahesh P. Kate
- Brian H Buck
- Thalia S. Field
Institutions
- Université de Tours (FR)
- Sunnybrook Health Science Centre (CA)
- University Health Network (CA)
- University of British Columbia (CA)
- University of Ottawa (CA)
- University of Alberta (CA)
- University of Calgary (CA)
- Toronto Western Hospital (CA)
- Ottawa Hospital (CA)
- Kelowna General Hospital (CA)
- Health Sciences Centre (CA)
- Population Health Research Institute (CA)
- University of Alberta Hospital (CA)
- University of Saskatchewan (CA)
- O'Brien Institute (AU)
- Centre Hospitalier Universitaire de Tours (FR)
- Ontario Brain Institute (CA)
Publication Details
- Journal
- Stroke
- Published
- 2026-01-29
- DOI
- https://doi.org/10.1161/strokeaha.125.054654
- Primary Topic
- Intracerebral and Subarachnoid Hemorrhage Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00