<i>Zeb2os</i> Hinders Cardiac Healing by Suppressing ZEB2 Reactivation and Cardiomyocyte Dedifferentiation
Our findings identify <i>Zeb2os</i> as a stress-responsive inhibitor of ZEB2 reactivation that limits cardiomyocyte plasticity and hinders repair following ischemic injury. Given its specific activity under ischemic conditions, targeting <i>Zeb2os</i> may represent a novel therapeutic strategy to enhance endogenous cardiac regeneration.
Authors
- Arnie Boender (ORCID: https://orcid.org/0009-0003-3709-9729)
- Merel L. Ligtermoet
- Vincent M. Christoffels (ORCID: https://orcid.org/0000-0003-4131-2636)
- Monika M Gladka (ORCID: https://orcid.org/0000-0002-4094-4335)
- Alexandra E. Giovou
- Liangyu Hu (ORCID: https://orcid.org/0000-0002-3476-9075)
- Lorena Zentilin (ORCID: https://orcid.org/0000-0001-7514-8155)
- Deli Zhang (ORCID: https://orcid.org/0000-0002-8891-9665)
- Rocco Caliandro (ORCID: https://orcid.org/0009-0006-7315-9209)
- Jermo Hanemaaijer-van der Veer
- Gerard J.J. Boink
- Huiling Zhou
- Roelof-Jan Oostra
- Azra Husetić
- Mauro Giacca
Institutions
- King's College London (GB)
- Leiden University Medical Center (NL)
- British Heart Foundation (GB)
- John Benjamins Publishing Company (Netherlands) (NL)
- Amsterdam University Medical Centers (NL)
- Vrije Universiteit Amsterdam (NL)
- International Centre for Genetic Engineering and Biotechnology (IT)
- Wageningen University & Research (NL)
Publication Details
- Journal
- Circulation Research
- Published
- 2026-01-29
- DOI
- https://doi.org/10.1161/circresaha.125.327212
- Citations
- 1
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 24.82