Impaired CD4+ T-cell and CD4+/CD8+ ratio recovery among people with HIV on antiretroviral therapy: prevalence and risk factors

While most PWH with ongoing viral suppression will recover their CD4+ cell counts, recovery of CD4+/CD8+ ratio recovery is less common, indicating ongoing immune dysfunction. Several demographic and clinical factors are associated with impaired immune recovery. Further characterization and understanding of the long-term impact of impaired immune recovery is needed.

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Publication Details

Journal
AIDS
Published
2026-01-29
DOI
https://doi.org/10.1097/qad.0000000000004456
Primary Topic
HIV Research and Treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

Impaired CD4+ T-cell and CD4+/CD8+ ratio recovery among people with HIV on antiretroviral therapy: prevalence and risk factors

Layla Al-Yasiri, Raynell Lang, Hartmut Krentz, M. John Gill et al.
AIDS
HIV Research and Treatment
article

Impaired CD4+ T-cell and CD4+/CD8+ ratio recovery among people with HIV on antiretroviral therapy: prevalence and risk factors

Layla Al-Yasiri, Raynell Lang, Hartmut Krentz, M. John Gill, Jaqueline McMillan
article en

Abstract

While most PWH with ongoing viral suppression will recover their CD4+ cell counts, recovery of CD4+/CD8+ ratio recovery is less common, indicating ongoing immune dysfunction. Several demographic and clinical factors are associated with impaired immune recovery. Further characterization and understanding of the long-term impact of impaired immune recovery is needed.

AIDS
Alberta Health Services (CA), University of Calgary (CA), South Health Campus (CA)
Good health and well-being
Openalex Percentile: Top 74%
HIV Research and Treatment
DOISourceOpenAlex
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Impaired CD4+ T-cell and CD4+/CD8+ ratio recovery among people with HIV on antiretroviral therapy: prevalence and risk factors — Layla Al-Yasiri, Raynell Lang, et al. · AIDS (2026) | TGRS Research Map | TGRS