Association Between Glucagon-Like Peptide-1 Receptor Agonists and Major Adverse Cardiovascular Outcomes Based on Race and Sex Among Patients With and Without Diabetes Mellitus: A Meta-Analysis of Nine Randomized Controlled Trials
This meta-analysis demonstrates that GLP-1 RAs significantly reduce the risk of MACEs in both males and females, as well as across various racial groups in patients with or without T2DM. However, the lack of significant benefit in Black patients suggests potential racial disparities in the enrollment and efficacy of GLP-1 RAs for cardiovascular outcomes.
Authors
- Nirmit Patel (ORCID: https://orcid.org/0000-0002-3249-0687)
- Pooja Sharma (ORCID: https://orcid.org/0000-0003-0146-5785)
- Asmita Gera (ORCID: https://orcid.org/0000-0002-0312-8208)
- Yusra Nasir
- Jishanth Mattumpuram (ORCID: https://orcid.org/0000-0002-6359-3435)
- Yusra Mashkoor (ORCID: https://orcid.org/0000-0001-7943-7106)
- Vamsikalyan Borra (ORCID: https://orcid.org/0000-0002-9595-5699)
- Sahas Reddy Jitta
- Vikash Jaiswal
Institutions
- Maimonides Medical Center (US)
- University of Louisville (US)
- Illinois Tool Works (United States) (US)
- Pikeville Medical Center (US)
- King George's Medical University (IN)
- University of Saint Mary (US)
- Dow University of Health Sciences (PK)
- St. Mary's Hospital (US)
- Mercy Hospital (US)
- University of Oklahoma Health Sciences Center (US)
Publication Details
- Journal
- Reviews in Cardiovascular Medicine
- Published
- 2026-01-21
- DOI
- https://doi.org/10.31083/rcm45797
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00