Integrative transcriptomics, machine learning, and molecular docking reveal that nicotine exacerbates ischemic stroke: TLR4-dependent activation of NLRP3/caspase-1/GSDMD-mediated microglial pyroptosis
Nic accelerates IS progression by modulating pyroptosis and chronic inflammatory signaling. This combined computational-experimental approach provides novel mechanistic insights into Nic-induced stroke pathology and highlights potential molecular targets for therapeutic intervention.
Authors
- Dan Xin
- Qian Wang (ORCID: https://orcid.org/0000-0003-4755-7001)
- Yuxia Ma (ORCID: https://orcid.org/0009-0007-2394-3430)
- Tianxiao Zhu
- Yuxuan Duan
- Yeqin Wang
- Xianjia Li
- Xiaoqi Ma
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
- Fourth People’s Hospital of Jinan (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2026-01-29
- DOI
- https://doi.org/10.1097/js9.0000000000004922
- Citations
- 1
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 22.24