Stem cell engineering for the generation of allogeneic CAR-directed natural killer T cells targeting endometrial carcinoma
These findings highlight the potential of <sup>Allo</sup>MCAR-NKT cells as a safe and effective off-the-shelf cellular immunotherapy for the treatment of UEC and potentially other solid tumors characterized by an immunosuppressive microenvironment.
Authors
- Ryan Hon
- Neda A. Moatamed (ORCID: https://orcid.org/0000-0002-9986-8058)
- Sanaz Memarzadeh
- Adam Neal (ORCID: https://orcid.org/0000-0002-8616-4860)
- Gabriella DiBernardo (ORCID: https://orcid.org/0000-0001-8022-7288)
- Lauryn Ruegg
- Yuning Chen
- Lili Yang
- Yan-Ruide Li
- Xinyuan Shen
- Jie Huang
Institutions
- University of California, Los Angeles (US)
- Parker Institute for Cancer Immunotherapy (US)
- Broad Center (US)
- VA Greater Los Angeles Healthcare System (US)
Publication Details
- Journal
- Experimental Hematology and Oncology
- Published
- 2026-01-29
- DOI
- https://doi.org/10.1186/s40164-026-00746-8
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00