Interferon levels and interferon-stimulated gene expression identify patient subsets with distinct clinical and immunological characteristics in systemic lupus erythematosus
All three IFN pathways were elevated in SLE. Correlation of IFNα levels and IFN score with SLEDAI suggested their potential as possible biomarker for monitoring disease activity. Association of IFNλ4 with IFN score suggested their possible role in IFN pathway activation.By assessing IFNs at both protein and transcriptional levels, present study provided comprehensive insight into IFN pathway dynamics and IFN-driven heterogeneity in SLE.
Authors
- S. K. Patil
- S H Kini
- Prathamesh Warang
- Aman Ullah Malik (ORCID: https://orcid.org/0000-0001-5211-5668)
- M Y Nadkar
- Swapnal Pawaskar
- Pooja Jaiswal (ORCID: https://orcid.org/0009-0000-7957-3116)
- Kavyasree Raj S.
- Anjali M. Rajadhyaksha (ORCID: https://orcid.org/0000-0002-8399-5466)
- Seema Korgaonkar
- Kalpana Mehta
- Amrutha Jose
- Nilesh Nolkha
- Harshada Konkar
- Ridi Khatri
- Kirti Rai
- Ajit Kumar Das
- Pratiksha Pawar
- Vandana D. Pradhan
- Manisha Madkaikar
Institutions
- King Edward Memorial Hospital and Seth G.S. Medical College (IN)
- Topiwala National Medical College & BYL Nair Charitable Hospital (IN)
- ICMR - National Institute of Immunohaemotology (IN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-29
- DOI
- https://doi.org/10.3389/fimmu.2026.1757895
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00