Airway microbiome dysbiosis in severe pneumonia: metagenomic evidence of pathogen expansion and commensal depletion

Our multicenter observational analysis suggests that severe pneumonia is associated with marked ecological disruption of the lower-airway microbiome, characterized by commensal loss, opportunist expansion, and fragmented interspecies networks, and with concurrent inflammatory and coagulative abnormalities. These hypothesis-generating findings warrant external validation in independent, multi-region cohorts and longitudinal sampling to test directionality and causality before informing clinical decision-making.

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Publication Details

Journal
European journal of medical research
Published
2026-01-29
DOI
https://doi.org/10.1186/s40001-026-03892-1
Primary Topic
Gut microbiota and health
Type
article
Field-Weighted Citation Impact
0.00
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article

Airway microbiome dysbiosis in severe pneumonia: metagenomic evidence of pathogen expansion and commensal depletion

Yuanlin Song, Tianchang Wei, Ruilan Wang, Jianwen Bai et al.
European journal of medical research
Gut microbiota and health
article

Airway microbiome dysbiosis in severe pneumonia: metagenomic evidence of pathogen expansion and commensal depletion

Yuanlin Song, Tianchang Wei, Ruilan Wang, Jianwen Bai, Zhijun Jie, Jian Xu, Jie Shen, Xueling Wu, Yao Shen, Dongni Hou, Yuhan Wang, Feng Li, Jing Bi
article en

Abstract

Our multicenter observational analysis suggests that severe pneumonia is associated with marked ecological disruption of the lower-airway microbiome, characterized by commensal loss, opportunist expansion, and fragmented interspecies networks, and with concurrent inflammatory and coagulative abnormalities. These hypothesis-generating findings warrant external validation in independent, multi-region cohorts and longitudinal sampling to test directionality and causality before informing clinical decision-making.

European journal of medical researchVol. 31(1)
Fudan University (CN), Renji Hospital (CN), Shanghai FRP Research Institute (China) (CN), Jinshan Hospital of Fudan University (CN), Shanghai Public Health Clinical Center (CN), Zhongshan Hospital (CN), Pudong Medical Center (CN), Shanghai East Hospital (CN), Shanghai First People's Hospital (CN), Huashan Hospital (CN)
Peace, Justice and strong institutions
Openalex Percentile: Top 74%
Gut microbiota and health
DOIOpen Access PDFOpenAlex
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Airway microbiome dysbiosis in severe pneumonia: metagenomic evidence of pathogen expansion and commensal depletion — Yuanlin Song, Tianchang Wei, et al. · European journal of medical research (2026) | TGRS Research Map | TGRS