Abstract WP186: Stroke Related Mortality Trends In Patients With Colorectal Carcinoma, A Two Decade Analytical Study

Introduction: Colorectal cancer (CRC) is the most prevalent cancer worldwide and second leading cause of cancer-related deaths in the United States, with an estimated 53,010 deaths anticipated in 2024. Stroke, especially ischemic is a feared complication of cancer and is thought to be higher in carcinomas caused by smoking i.e. Lung and Colorectal. In this study, we examine the mortality trends due to Stroke and CRC in the US and in turn conceptualize the prevention and care strategies. Methods: Using the CDC WONDER database, we analyzed annual age adjusted mortality rates (AAMR) per million from 1990-2020 in Stroke and CRC patients. Trends were analyzed and annual percent change (APC) and the average annual percent change (AAPC) was calculated using the JoinPoint regression model across variations in demographics and regional subgroups. Results: From 1999-2020, a total of 32,743 deaths occurred due to stroke and CRC, and the overall trend was declining with AAPC of -4.78%(CI -5.34 to -4.22 pvalue < 0.05). Across different age groups, people above the age of 85 recorded the most deaths (n = 12,224), however the rate of decline was more in people aged 75-84 years with AAPC of -5.6%, followed by 85+ age group(-5.4%). Demographically, the mortality count in women was higher as compared to men [n(w) = 17,169 vs n(m) = 15,574)], the trend also favored females as the rate of decline was more among them in contrast to males[AAPC(f) = -5.0% vs AAPC(m) = -4.6%]. Racially, mortality rate was highest amongst Whites (n = 26,610) as compared to other races, however rate of decline was more pronounced in African Americans which showed AAPC of -5.6%, followed by Asian or Pacific Islanders(AAPC = -5.0%), Whites(AAPC = -4.7%), and Hispanics(AAPC = -4.3%). Regionally, the South showed the highest mortality rate (n = 11,405), followed by the Midwest (n = 8,373), however the rate of decline favored Northeast with the recorded AAPC of -5.6%, followed by Midwest(-5.3%) and West(-4.6%). Areas based analysis showed that mortality rate was more prominent among urban populations as compared to rural areas [n(u) = 25,533 vs n(r) = 7,210], the trend also favored Urban population as the rate of decline was higher with AAPC of -4.9% than Rural populations(-4.0%). Conclusion: Though the mortality due to stroke in CRC patients has declined in the past 21 years, disparities remain across demographic and regional groups, highlighting the need for targeted interventions and better policy making.